PT - JOURNAL ARTICLE AU - Russell, M AU - Dark, KA AU - Cummins, RW AU - Ellman, G AU - Callaway, E AU - Peeke, HV TI - Learned histamine release AID - 10.1126/science.6205449 DP - 1984 Aug 17 TA - Science PG - 733--734 VI - 225 IP - 4663 4099 - http://science.sciencemag.org/content/225/4663/733.short 4100 - http://science.sciencemag.org/content/225/4663/733.full SO - Science1984 Aug 17; 225 AB - Most of the effort directed at understanding the problems of allergy has focused on the interacting components of the immune system. The possibility that histamine may be released as a learned response has now been tested. In a classical conditioning procedure in which an immunologic challenge was paired with the presentation of an odor, guinea pigs showed a plasma histamine increase when presented with the odor alone. This suggests that the immune response can be enhanced through activity of the central nervous system.