PT  - JOURNAL ARTICLE
AU  - Russell, M
AU  - Dark, KA
AU  - Cummins, RW
AU  - Ellman, G
AU  - Callaway, E
AU  - Peeke, HV
TI  - Learned histamine release
AID  - 10.1126/science.6205449
DP  - 1984 Aug 17
TA  - Science
PG  - 733--734
VI  - 225
IP  - 4663
4099  - http://science.sciencemag.org/content/225/4663/733.short
4100  - http://science.sciencemag.org/content/225/4663/733.full
SO  - Science1984 Aug 17; 225
AB  - Most of the effort directed at understanding the problems of allergy has focused on the interacting components of the immune system. The possibility that histamine may be released as a learned response has now been tested. In a classical conditioning procedure in which an immunologic challenge was paired with the presentation of an odor, guinea pigs showed a plasma histamine increase when presented with the odor alone. This suggests that the immune response can be enhanced through activity of the central nervous system.