RT Journal Article
SR Electronic
T1 Differential control of U1 small nuclear RNA expression during mouse development
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1271
OP 1274
DO 10.1126/science.2412294
VO 229
IS 4719
A1 Lund, E
A1 Kahan, B
A1 Dahlberg, JE
YR 1985
UL http://science.sciencemag.org/content/229/4719/1271.abstract
AB During normal mouse development the relative amounts of two types of U1 small nuclear RNA's (U1 RNA) change significantly. Fetal tissues have comparable levels of the two major types of mouse U1 RNA's, mU1a and mU1b, whereas most differentiated adult tissues contain only mU1a RNA's. Those adult tissues that also accumulate detectable amounts of embryonic (mU1b) RNA's (for example, testis, spleen, and thymus) contain a significant proportion of stem cells capable of further differentiation. Several strains of mice express minor sequence variants of U1 RNA's that are subject to the same developmental controls as the major types of adult and embryonic U1 RNA. The differential accumulation of embryonic U1 RNA's may influence the pattern of gene expression during early development and differentiation.