PT  - JOURNAL ARTICLE
AU  - Hattori, M
AU  - Buse, JB
AU  - Jackson, RA
AU  - Glimcher, L
AU  - Dorf, ME
AU  - Minami, M
AU  - Makino, S
AU  - Moriwaki, K
AU  - Kuzuya, H
AU  - Imura, H
AU  - et, al.
TI  - The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex
AID  - 10.1126/science.3003909
DP  - 1986 Feb 14
TA  - Science
PG  - 733--735
VI  - 231
IP  - 4739
4099  - http://science.sciencemag.org/content/231/4739/733.short
4100  - http://science.sciencemag.org/content/231/4739/733.full
SO  - Science1986 Feb 14; 231
AB  - Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.