PT  - JOURNAL ARTICLE
AU  - DiMarchi, R
AU  - Brooke, G
AU  - Gale, C
AU  - Cracknell, V
AU  - Doel, T
AU  - Mowat, N
TI  - Protection of cattle against foot-and-mouth disease by a synthetic peptide
AID  - 10.1126/science.3008333
DP  - 1986 May 02
TA  - Science
PG  - 639--641
VI  - 232
IP  - 4750
4099  - http://science.sciencemag.org/content/232/4750/639.short
4100  - http://science.sciencemag.org/content/232/4750/639.full
SO  - Science1986 May 02; 232
AB  - A chemically synthesized peptide consisting essentially of two separate regions (residues 141 to 158 and 200 to 213) of a virus coat protein (VP1) from the O1 Kaufbeuren strain of foot-and-mouth disease virus was prepared free of any carrier protein. It elicited high levels of neutralizing antibody and protected cattle against intradermolingual challenge by inoculation with infectious virus. Comparative evaluation of this peptide with a single-site peptide (residues 141 to 158) in guinea pigs suggests the importance of the VP1 carboxyl terminal residues in enhancing the protective response.