PT  - JOURNAL ARTICLE
AU  - Celio, MR
TI  - Parvalbumin in most gamma-aminobutyric acid-containing neurons of the rat cerebral cortex
AID  - 10.1126/science.3945815
DP  - 1986 Feb 28
TA  - Science
PG  - 995--997
VI  - 231
IP  - 4741
4099  - http://science.sciencemag.org/content/231/4741/995.short
4100  - http://science.sciencemag.org/content/231/4741/995.full
SO  - Science1986 Feb 28; 231
AB  - gamma-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.