RT Journal Article
SR Electronic
T1 Parvalbumin in most gamma-aminobutyric acid-containing neurons of the rat cerebral cortex
JF Science
JO Science
FD American Association for the Advancement of Science
SP 995
OP 997
DO 10.1126/science.3945815
VO 231
IS 4741
A1 Celio, MR
YR 1986
UL http://science.sciencemag.org/content/231/4741/995.abstract
AB gamma-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.