PT  - JOURNAL ARTICLE
AU  - Mason, AJ
AU  - Hayflick, JS
AU  - Zoeller, RT
AU  - Young, WS
AU  - Phillips, HS
AU  - Nikolics, K
AU  - Seeburg, PH
TI  - A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse
AID  - 10.1126/science.3024317
DP  - 1986 Dec 12
TA  - Science
PG  - 1366--1371
VI  - 234
IP  - 4782
4099  - http://science.sciencemag.org/content/234/4782/1366.short
4100  - http://science.sciencemag.org/content/234/4782/1366.full
SO  - Science1986 Dec 12; 234
AB  - Hereditary hypogonadism in the hypogonadal (hpg) mouse is caused by a deletional mutation of at least 33.5 kilobases encompassing the distal half of the gene for the common biosynthetic precursor of gonadotropin-releasing hormone (GnRH) and GnRH-associated peptide (GAP). The partially deleted gene is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.