PT  - JOURNAL ARTICLE
AU  - Kobilka, BK
AU  - Matsui, H
AU  - Kobilka, TS
AU  - Yang-Feng, TL
AU  - Francke, U
AU  - Caron, MG
AU  - Lefkowitz, RJ
AU  - Regan, JW
TI  - Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
AID  - 10.1126/science.2823383
DP  - 1987 Oct 30
TA  - Science
PG  - 650--656
VI  - 238
IP  - 4827
4099  - http://science.sciencemag.org/content/238/4827/650.short
4100  - http://science.sciencemag.org/content/238/4827/650.full
SO  - Science1987 Oct 30; 238
AB  - The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor. The identity of this gene has been confirmed by the binding of alpha 2-adrenergic ligands to the cloned receptor expressed in Xenopus laevis oocytes. The deduced amino acid sequence is most similar to the recently cloned human beta 2- and beta 1-adrenergic receptors; however, similarities to the muscarinic cholinergic receptors are also evident. Two related genes have been identified by low stringency Southern blot analysis. These genes may represent additional alpha 2-adrenergic receptor subtypes.