PT - JOURNAL ARTICLE AU - Evans, RM TI - The steroid and thyroid hormone receptor superfamily AID - 10.1126/science.3283939 DP - 1988 May 13 TA - Science PG - 889--895 VI - 240 IP - 4854 4099 - http://science.sciencemag.org/content/240/4854/889.short 4100 - http://science.sciencemag.org/content/240/4854/889.full SO - Science1988 May 13; 240 AB - Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.