RT Journal Article
SR Electronic
T1 Effect of neuropeptides on production of inflammatory cytokines by human monocytes
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1218
OP 1221
DO 10.1126/science.2457950
VO 241
IS 4870
A1 Lotz, M
A1 Vaughan, JH
A1 Carson, DA
YR 1988
UL http://science.sciencemag.org/content/241/4870/1218.abstract
AB Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived cytokines, interact in the neural regulation of immunological and inflammatory responses. Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 from human blood monocytes. The neuropeptide effects occur at low doses, are specific as shown by inhibition studies with a substance P antagonist, and require de novo protein synthesis. Since monocyte-derived cytokines regulate multiple cellular functions in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues, these findings identify a potent mechanism for nervous system regulation of host defense responses.