PT  - JOURNAL ARTICLE
AU  - VanDongen, AM
AU  - Codina, J
AU  - Olate, J
AU  - Mattera, R
AU  - Joho, R
AU  - Birnbaumer, L
AU  - Brown, AM
TI  - Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go
AID  - 10.1126/science.3144040
DP  - 1988 Dec 09
TA  - Science
PG  - 1433--1437
VI  - 242
IP  - 4884
4099  - http://science.sciencemag.org/content/242/4884/1433.short
4100  - http://science.sciencemag.org/content/242/4884/1433.full
SO  - Science1988 Dec 09; 242
AB  - Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.