RT Journal Article
SR Electronic
T1 Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1433
OP 1437
DO 10.1126/science.3144040
VO 242
IS 4884
A1 VanDongen, AM
A1 Codina, J
A1 Olate, J
A1 Mattera, R
A1 Joho, R
A1 Birnbaumer, L
A1 Brown, AM
YR 1988
UL http://science.sciencemag.org/content/242/4884/1433.abstract
AB Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.