PT  - JOURNAL ARTICLE
AU  - Lindstein, T
AU  - June, CH
AU  - Ledbetter, JA
AU  - Stella, G
AU  - Thompson, CB
TI  - Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
AID  - 10.1126/science.2540528
DP  - 1989 Apr 21
TA  - Science
PG  - 339--343
VI  - 244
IP  - 4902
4099  - http://science.sciencemag.org/content/244/4902/339.short
4100  - http://science.sciencemag.org/content/244/4902/339.full
SO  - Science1989 Apr 21; 244
AB  - Quiescent T cells can be induced to express many genes by mitogen or antigen stimulation. The messenger RNAs of some of these genes undergo relatively rapid degradation compared to messenger RNAs from constitutively expressed genes. A T cell activation pathway that specifically regulates the stability of messenger RNAs for the lymphokines interleukin-2, interferon-gamma, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor is induced by stimulation of the CD28 surface molecule. This pathway does not directly affect the steady-state messenger RNA level, transcription, or messenger RNA half-life of other T cell activation genes, including c-myc, c-fos, IL-2 receptor, and the 4F2HC surface antigen. These data show that stimuli received at the cell surface can alter gene expression by inducing specific changes in messenger RNA degradation.