PT  - JOURNAL ARTICLE
AU  - O'Connell, P
AU  - Leach, R
AU  - Cawthon, RM
AU  - Culver, M
AU  - Stevens, J
AU  - Viskochil, D
AU  - Fournier, RE
AU  - Rich, DC
AU  - Ledbetter, DH
AU  - White, R
TI  - Two NF1 translocations map within a 600-kilobase segment of 17q11.2
AID  - 10.1126/science.2543077
DP  - 1989 Jun 02
TA  - Science
PG  - 1087--1088
VI  - 244
IP  - 4908
4099  - http://science.sciencemag.org/content/244/4908/1087.short
4100  - http://science.sciencemag.org/content/244/4908/1087.full
SO  - Science1989 Jun 02; 244
AB  - Balanced translocations, each involving chromosome 17q11.2, have been described in two patients with von Recklinghausen neurofibromatosis (NF1). To better localize the end points of these translocation events, and the NF1 gene (NF1) itself, human cosmids were isolated and mapped in the immediate vicinity of NF1. One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment.