PT  - JOURNAL ARTICLE
AU  - Payne, GS
AU  - Schekman, R
TI  - Clathrin: a role in the intracellular retention of a Golgi membrane protein
AID  - 10.1126/science.2675311
DP  - 1989 Sep 22
TA  - Science
PG  - 1358--1365
VI  - 245
IP  - 4924
4099  - http://science.sciencemag.org/content/245/4924/1358.short
4100  - http://science.sciencemag.org/content/245/4924/1358.full
SO  - Science1989 Sep 22; 245
AB  - Yeast mutants deficient in the clathrin heavy chain secrete a precursor form of the alpha-factor, a peptide-mating pheromone. Analysis of this defect indicates that the endoprotease Kex2p, which is responsible for initiating proteolytic maturation of the alpha-factor precursor in the Golgi apparatus, is unexpectedly present at the plasma membrane in mutant cells. This result suggest that clathrin is required for the retention of Kex2p in the Golgi apparatus.