PT  - JOURNAL ARTICLE
AU  - Rice, GE
AU  - Bevilacqua, MP
TI  - An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
AID  - 10.1126/science.2588007
DP  - 1989 Dec 08
TA  - Science
PG  - 1303--1306
VI  - 246
IP  - 4935
4099  - http://science.sciencemag.org/content/246/4935/1303.short
4100  - http://science.sciencemag.org/content/246/4935/1303.full
SO  - Science1989 Dec 08; 246
AB  - Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothelial cell surface glycoprotein, designated INCAM-110, appears to mediate adhesion of melanoma cells. In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line. Thus, activation of vascular endothelium in vivo that results in increased expression of INCAM-110 and ELAM-1 may promote tumor cell adhesion and affect the incidence and distribution of metastases.