RT Journal Article
SR Electronic
T1 Thymic epithelium tolerizes for histocompatibility antigens
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1471
OP 1474
DO 10.1126/science.2321009
VO 247
IS 4949
A1 Salaun, J
A1 Bandeira, A
A1 Khazaal, I
A1 Calman, F
A1 Coltey, M
A1 Coutinho, A
A1 Le Douarin, NM
YR 1990
UL http://science.sciencemag.org/content/247/4949/1471.abstract
AB The role of thymic epithelium in the establishment of tissue tolerance was analyzed with a murine chimeric system. All T cells differentiated from birth onward in a thymus comprising allogeneic epithelium and syngeneic hematopoietic cells. Embryonic thymic rudiments that contained no hematopoietic cells from C3H (H-2k) donors were grafted to newborn athymic (nude) BALB/c (H-2d) mice. Chimeras that had normal T cell numbers and function rejected third-party skin grafts, but permanently accepted grafts syngeneic to the thymic epithelium. In vitro functional assays did not always correlate with the state of tolerance in vivo. Thus, pure thymic epithelium induces tolerance to histocompatibility antigens.