RT Journal Article
SR Electronic
T1 Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1234
OP 1237
DO 10.1126/science.2190315
VO 248
IS 4960
A1 Orentas, RJ
A1 Hildreth, JE
A1 Obah, E
A1 Polydefkis, M
A1 Smith, GE
A1 Clements, ML
A1 Siliciano, RF
YR 1990
UL http://science.sciencemag.org/content/248/4960/1234.abstract
AB Cytolytic T lymphocyte (CTL) responses were evaluated in humans immunized with recombinant human immunodeficiency virus type 1 (HIV) envelope glycoprotein gp160. Some vaccinees had gp160-specific CTLs that were shown by cloning to be CD4+. Although induced by exogenous antigen, most gp160-specific CTL clones also recognized gp160 synthesized endogenously in target cells. These clones lysed autologous CD4+ T lymphoblasts infected with HIV. Of particular interest were certain vaccine-induced clones that lysed HIV-infected cells, recognized gp160 from diverse HIV isolates, and did not participate in "innocent bystander" killing of noninfected CD4+ T cells that had bound gp120.