PT  - JOURNAL ARTICLE
AU  - Burkly, LC
AU  - Lo, D
AU  - Flavell, RA
TI  - Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells
AID  - 10.1126/science.1694042
DP  - 1990 Jun 15
TA  - Science
PG  - 1364--1368
VI  - 248
IP  - 4961
4099  - http://science.sciencemag.org/content/248/4961/1364.short
4100  - http://science.sciencemag.org/content/248/4961/1364.full
SO  - Science1990 Jun 15; 248
AB  - Transgenic mice with defined expression of major histocompatibility complex (MHC) proteins provide novel systems for understanding the fundamental question of T cell tolerance to nonlymphoid self components. The MHC class II I-E and I-A and class I H-2K molecules expressed specifically on pancreatic islet or acinar cells serve as model self antigens. In these systems, transgenic proteins are not detected in the thymus or other lymphoid tissues. Yet mice are tolerant to the pancreatic MHC products in vivo; this tolerance is not induced by clonal deletion. These studies have been aided by monoclonal antibodies specific for I-E-reactive T cells and indicate that clonal anergy may be an important mechanism of tolerance to peripheral proteins.