PT  - JOURNAL ARTICLE
AU  - Garry, RF
AU  - Fermin, CD
AU  - Hart, DJ
AU  - Alexander, SS
AU  - Donehower, LA
AU  - Luo-Zhang, H
TI  - Detection of a human intracisternal A-type retroviral particle antigenically related to HIV
AID  - 10.1126/science.1701273
DP  - 1990 Nov 23
TA  - Science
PG  - 1127--1129
VI  - 250
IP  - 4984
4099  - http://science.sciencemag.org/content/250/4984/1127.short
4100  - http://science.sciencemag.org/content/250/4984/1127.full
SO  - Science1990 Nov 23; 250
AB  - Sjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.