RT Journal Article
SR Electronic
T1 Detection of a human intracisternal A-type retroviral particle antigenically related to HIV
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1127
OP 1129
DO 10.1126/science.1701273
VO 250
IS 4984
A1 Garry, RF
A1 Fermin, CD
A1 Hart, DJ
A1 Alexander, SS
A1 Donehower, LA
A1 Luo-Zhang, H
YR 1990
UL http://science.sciencemag.org/content/250/4984/1127.abstract
AB Sjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.