RT Journal Article
SR Electronic
T1 Chemistry and biology of the immunophilins and their immunosuppressive ligands
JF Science
JO Science
FD American Association for the Advancement of Science
SP 283
OP 287
DO 10.1126/science.1702904
VO 251
IS 4991
A1 Schreiber, SL
YR 1991
UL http://science.sciencemag.org/content/251/4991/283.abstract
AB Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.