PT  - JOURNAL ARTICLE
AU  - Lo, SC
AU  - Tsai, S
AU  - Benish, 
AU  - Shih, JW
AU  - Wear, DJ
AU  - Wong, DM
TI  - Enhancement of HIV-1 cytocidal effects in CD4+ lymphocytes by the AIDS-associated mycoplasma
AID  - 10.1126/science.1705362
DP  - 1991 Mar 01
TA  - Science
PG  - 1074--1076
VI  - 251
IP  - 4997
4099  - http://science.sciencemag.org/content/251/4997/1074.short
4100  - http://science.sciencemag.org/content/251/4997/1074.full
SO  - Science1991 Mar 01; 251
AB  - Coinfection with Mycoplasma fermentans (incognitus strain) enhances the ability of human immunodeficiency virus type-1 (HIV-1) to induce cytopathic effects on human T lymphocytes in vitro. Syncytium formation of HIV-infected T cells was essentially eliminated in the presence of M. fermentans (incognitus strain), despite prominent cell death. However, replication and production of HIV-1 particles continued during the coinfection. Furthermore, the supernatant from cultures coinfected with HIV-1 and the mycoplasma contained a factor that inhibited the standard reverse transcriptase enzyme assay. The modification of the biological properties of HIV-1 by coinfection with mycoplasma may be involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS).