RT Journal Article
SR Electronic
T1 A corticosteroid receptor in neuronal membranes
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1848
OP 1851
DO 10.1126/science.2063198
VO 252
IS 5014
A1 Orchinik, M
A1 Murray, TF
A1 Moore, FL
YR 1991
UL http://science.sciencemag.org/content/252/5014/1848.abstract
AB Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.