PT  - JOURNAL ARTICLE
AU  - Bellacosa, A
AU  - Testa, 
AU  - Staal, SP
AU  - Tsichlis, PN
TI  - A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
AID  - 10.1126/science.1833819
DP  - 1991 Oct 11
TA  - Science
PG  - 274--277
VI  - 254
IP  - 5029
4099  - http://science.sciencemag.org/content/254/5029/274.short
4100  - http://science.sciencemag.org/content/254/5029/274.full
SO  - Science1991 Oct 11; 254
AB  - The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.