RT Journal Article
SR Electronic
T1 A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
JF Science
JO Science
FD American Association for the Advancement of Science
SP 274
OP 277
DO 10.1126/science.1833819
VO 254
IS 5029
A1 Bellacosa, A
A1 Testa,
A1 Staal, SP
A1 Tsichlis, PN
YR 1991
UL http://science.sciencemag.org/content/254/5029/274.abstract
AB The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.