RT Journal Article
SR Electronic
T1 Molecular basis of latency in pathogenic human viruses
JF Science
JO Science
FD American Association for the Advancement of Science
SP 815
OP 820
DO 10.1126/science.1658933
VO 254
IS 5033
A1 Garcia-Blanco, MA
A1 Cullen, BR
YR 1991
UL http://science.sciencemag.org/content/254/5033/815.abstract
AB Several human viruses are able to latently infect specific target cell populations in vivo. Analysis of the replication cycles of herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus suggests that the latent infections established by these human pathogens primarily result from a lack of host factors critical for the expression of viral early gene products. The subsequent activation of specific cellular transcription factors in response to extracellular stimuli can induce the expression of these viral regulatory proteins and lead to a burst of lytic viral replication. Latency in these eukaryotic viruses therefore contrasts with latency in bacteriophage, which is maintained primarily by the expression of virally encoded repressors of lytic replication.