PT  - JOURNAL ARTICLE
AU  - Kishimoto, T
AU  - Akira, S
AU  - Taga, T
TI  - Interleukin-6 and its receptor: a paradigm for cytokines
AID  - 10.1126/science.1411569
DP  - 1992 Oct 23
TA  - Science
PG  - 593--597
VI  - 258
IP  - 5082
4099  - http://science.sciencemag.org/content/258/5082/593.short
4100  - http://science.sciencemag.org/content/258/5082/593.full
SO  - Science1992 Oct 23; 258
AB  - Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis of these diseases and therapies to treat them will be discussed based on insights derived from cytokine research.