PT  - JOURNAL ARTICLE
AU  - Couso, JP
AU  - Bate, M
AU  - Martinez-Arias, A
TI  - A wingless-dependent polar coordinate system in Drosophila imaginal discs
AID  - 10.1126/science.8424170
DP  - 1993 Jan 22
TA  - Science
PG  - 484--489
VI  - 259
IP  - 5094
4099  - http://science.sciencemag.org/content/259/5094/484.short
4100  - http://science.sciencemag.org/content/259/5094/484.full
SO  - Science1993 Jan 22; 259
AB  - The patterning of the imaginal discs in Drosophila melanogaster is a progressive process that, like the patterning of the larval epidermis during embryogenesis, requires the activity of segment polarity genes. One segment polarity gene, wingless, encodes a homolog of the mouse proto-oncogene Wnt-1 and plays a prominent role in the patterning of the larval epidermis and the imaginal discs. However, whereas the function of wingless in the embryo is initially associated with a pattern of stripes along the anteroposterior axis that are part of a Cartesian coordinate system, it is shown here that during imaginal development wingless is associated with a pattern of sectors that provide references for a polar coordinate system homologous to that postulated in a well-known model for the regeneration of insect and vertebrate limbs.