PT  - JOURNAL ARTICLE
AU  - Huang, S
AU  - Hendriks, W
AU  - Althage, A
AU  - Hemmi, S
AU  - Bluethmann, H
AU  - Kamijo, R
AU  - Vilcek, J
AU  - Zinkernagel, RM
AU  - Aguet, M
TI  - Immune response in mice that lack the interferon-gamma receptor
AID  - 10.1126/science.8456301
DP  - 1993 Mar 19
TA  - Science
PG  - 1742--1745
VI  - 259
IP  - 5102
4099  - http://science.sciencemag.org/content/259/5102/1742.short
4100  - http://science.sciencemag.org/content/259/5102/1742.full
SO  - Science1993 Mar 19; 259
AB  - Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.