PT  - JOURNAL ARTICLE
AU  - Lamb, TM
AU  - Knecht, AK
AU  - Smith, WC
AU  - Stachel, SE
AU  - Economides, AN
AU  - Stahl, N
AU  - Yancopolous, GD
AU  - Harland, RM
TI  - Neural induction by the secreted polypeptide noggin
AID  - 10.1126/science.8235591
DP  - 1993 Oct 29
TA  - Science
PG  - 713--718
VI  - 262
IP  - 5134
4099  - http://science.sciencemag.org/content/262/5134/713.short
4100  - http://science.sciencemag.org/content/262/5134/713.full
SO  - Science1993 Oct 29; 262
AB  - The Spermann organizer induces neural tissue from dorsal ectoderm and dorsalizes lateral and ventral mesoderm in Xenopus. The secreted factor noggin, which is expressed in the organizer, can mimic the dorsalizing signal of the organizer. Data are presented showing that noggin directly induces neural tissue, that it induces neural tissue in the absence of dorsal mesoderm, and that it acts at the appropriate stage to be an endogenous neural inducing signal. Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer.