RT Journal Article
SR Electronic
T1 FGF-2: apical ectodermal ridge growth signal for chick limb development
JF Science
JO Science
FD American Association for the Advancement of Science
SP 104
OP 107
DO 10.1126/science.7908145
VO 264
IS 5155
A1 Fallon, JF
A1 Lopez, A
A1 Ros, MA
A1 Savage, MP
A1 Olwin, BB
A1 Simandl, BK
YR 1994
UL http://science.sciencemag.org/content/264/5155/104.abstract
AB The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.