RT Journal Article SR Electronic T1 Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless JF Science JO Science FD American Association for the Advancement of Science SP 1603 OP 1606 DO 10.1126/science.8128246 VO 263 IS 5153 A1 Sehgal, A A1 Price, JL A1 Man, B A1 Young, MW YR 1994 UL http://science.sciencemag.org/content/263/5153/1603.abstract AB Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a clock mutation, timeless (tim), is described that produces arrhythmia for both behaviors. The effects of tim on behavioral rhythms are likely to involve products of the X chromosome-linked clock gene period (per), because tim alters circadian oscillations of per RNA. Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp).