RT Journal Article
SR Electronic
T1 Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1603
OP 1606
DO 10.1126/science.8128246
VO 263
IS 5153
A1 Sehgal, A
A1 Price, JL
A1 Man, B
A1 Young, MW
YR 1994
UL http://science.sciencemag.org/content/263/5153/1603.abstract
AB Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a clock mutation, timeless (tim), is described that produces arrhythmia for both behaviors. The effects of tim on behavioral rhythms are likely to involve products of the X chromosome-linked clock gene period (per), because tim alters circadian oscillations of per RNA. Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp).