PT  - JOURNAL ARTICLE
AU  - Reuther, GW
AU  - Fu, H
AU  - Cripe, LD
AU  - Collier, RJ
AU  - Pendergast, AM
TI  - Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family
AID  - 10.1126/science.7939633
DP  - 1994 Oct 07
TA  - Science
PG  - 129--133
VI  - 266
IP  - 5182
4099  - http://science.sciencemag.org/content/266/5182/129.short
4100  - http://science.sciencemag.org/content/266/5182/129.full
SO  - Science1994 Oct 07; 266
AB  - In this study, a protein that interacts with sequences encoded by the first exon of the protein kinase Bcr was cloned. The Bcr-associated protein 1 (Bap-1) is a member of the 14-3-3 family of proteins. Bap-1 interacts with full-length c-Bcr and with the chimeric Bcr-Abl tyrosine kinase of Philadelphia chromosome (Ph1)-positive human leukemias. Bap-1 is a substrate for the Bcr serine-threonine kinase and is also phosphorylated on tyrosine by Bcr-Abl but not by c-Abl. Bap-1 may function in the regulation of c-Bcr and may contribute to the transforming activity of Bcr-Abl in vivo. 14-3-3 proteins are essential for cell proliferation and have a role in determining the timing of mitosis in yeast. Through direct binding to sequences present in Bcr and in other proteins implicated in signaling, the mammalian 14-3-3 proteins may link specific signaling protein components to mitogenic and cell-cycle control pathways.