RT Journal Article
SR Electronic
T1 Enhanced aggressive behavior in mice lacking 5-HT1B receptor
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1875
OP 1878
DO 10.1126/science.8091214
VO 265
IS 5180
A1 Saudou, F
A1 Amara, DA
A1 Dierich, A
A1 LeMeur, M
A1 Ramboz, S
A1 Segu, L
A1 Buhot, MC
A1 Hen, R
YR 1994
UL http://science.sciencemag.org/content/265/5180/1875.abstract
AB The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.