RT Journal Article
SR Electronic
T1 Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1376
OP 1380
DO 10.1126/science.7973727
VO 266
IS 5189
A1 Smith, ML
A1 Chen, IT
A1 Zhan, Q
A1 Bae, I
A1 Chen, CY
A1 Gilmer, TM
A1 Kastan, MB
A1 O'Connor, PM
A1 Fornace, AJ
YR 1994
UL http://science.sciencemag.org/content/266/5189/1376.abstract
AB GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.