RT Journal Article
SR Electronic
T1 Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
JF Science
JO Science
FD American Association for the Advancement of Science
SP 891
OP 893
DO 10.1126/science.7531366
VO 267
IS 5199
A1 Boudreau, N
A1 Sympson, CJ
A1 Werb, Z
A1 Bissell, MJ
YR 1995
UL http://science.sciencemag.org/content/267/5199/891.abstract
AB Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.