RT Journal Article
SR Electronic
T1 Tyrosine kinase inhibition: an approach to drug development
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1782
OP 1788
DO 10.1126/science.7892601
VO 267
IS 5205
A1 Levitzki, A
A1 Gazit, A
YR 1995
UL http://science.sciencemag.org/content/267/5205/1782.abstract
AB Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine kinases and intracellular tyrosine kinases can lead to inflammatory responses and to diseases such as cancer, atherosclerosis, and psoriasis. Thus, inhibitors that block the activity of tyrosine kinases and the signaling pathways they activate may provide a useful basis for drug development. This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.