RT Journal Article SR Electronic T1 Tyrosine kinase inhibition: an approach to drug development JF Science JO Science FD American Association for the Advancement of Science SP 1782 OP 1788 DO 10.1126/science.7892601 VO 267 IS 5205 A1 Levitzki, A A1 Gazit, A YR 1995 UL http://science.sciencemag.org/content/267/5205/1782.abstract AB Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine kinases and intracellular tyrosine kinases can lead to inflammatory responses and to diseases such as cancer, atherosclerosis, and psoriasis. Thus, inhibitors that block the activity of tyrosine kinases and the signaling pathways they activate may provide a useful basis for drug development. This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.