RT Journal Article
SR Electronic
T1 Effects of the obese gene product on body weight regulation in ob/ob mice
JF Science
JO Science
FD American Association for the Advancement of Science
SP 540
OP 543
DO 10.1126/science.7624776
VO 269
IS 5223
A1 Pelleymounter, MA
A1 Cullen, MJ
A1 Baker, MB
A1 Hecht, R
A1 Winters, D
A1 Boone, T
A1 Collins, F
YR 1995
UL http://science.sciencemag.org/content/269/5223/540.abstract
AB C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob/ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.