PT - JOURNAL ARTICLE AU - Grant, MR AU - Godiard, L AU - Straube, E AU - Ashfield, T AU - Lewald, J AU - Sattler, A AU - Innes, RW AU - Dangl, JL TI - Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance AID - 10.1126/science.7638602 DP - 1995 Aug 11 TA - Science PG - 843--846 VI - 269 IP - 5225 4099 - http://science.sciencemag.org/content/269/5225/843.short 4100 - http://science.sciencemag.org/content/269/5225/843.full SO - Science1995 Aug 11; 269 AB - Plants can recognize pathogens through the action of disease resistance (R) genes, which confer resistance to pathogens expressing unique corresponding avirulence (avr) genes. The molecular basis of this gene-for-gene specificity is unknown. The Arabidopsis thaliana RPM1 gene enables dual specificity to pathogens expressing either of two unrelated Pseudomonas syringae avr genes. Despite this function, RPM1 encodes a protein sharing molecular features with recently described single-specificity R genes. Surprisingly, RPM1 is lacking from naturally occurring, disease-susceptible Arabidopsis accessions.