PT  - JOURNAL ARTICLE
AU  - Kuhn, R
AU  - Schwenk, F
AU  - Aguet, M
AU  - Rajewsky, K
TI  - Inducible gene targeting in mice
AID  - 10.1126/science.7660125
DP  - 1995 Sep 08
TA  - Science
PG  - 1427--1429
VI  - 269
IP  - 5229
4099  - http://science.sciencemag.org/content/269/5229/1427.short
4100  - http://science.sciencemag.org/content/269/5229/1427.full
SO  - Science1995 Sep 08; 269
AB  - A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.