PT  - JOURNAL ARTICLE
AU  - Sehgal, Amita
AU  - Rothenfluh-Hilfiker, Adrian
AU  - Hunter-Ensor, Melissa
AU  - Chen, Yifeng
AU  - Myers, Michael P.
AU  - Young, Michael W.
TI  - Rhythmic Expression of <em>timeless</em>: A Basis for Promoting Circadian Cycles in <em>period</em> Gene Autoregulation
AID  - 10.1126/science.270.5237.808
DP  - 1995 Nov 03
TA  - Science
PG  - 808--810
VI  - 270
IP  - 5237
4099  - http://science.sciencemag.org/content/270/5237/808.short
4100  - http://science.sciencemag.org/content/270/5237/808.full
SO  - Science1995 Nov 03; 270
AB  - The clock gene timeless (tim) is required for circadian rhythmicity in Drosophila. The accumulation of tim RNA followed a circadian rhythm, and the phase and period of the tim RNA rhythm were indistinguishable from those that have been reported for per. The tim RNA oscillations were found to be dependent on the presence of PER and TIM proteins, which demonstrates feedback control of tim by a mechanism previously shown to regulate per expression. The cyclic expression of tim appears to dictate the timing of PER protein accumulation and nuclear localization, suggesting that tim promotes circadian rhythms of per and tim transcription by restricting per RNA and PER protein accumulation to separate times of day.