PT  - JOURNAL ARTICLE
AU  - Rice, William G.
AU  - Supko, Jeffrey G.
AU  - Malspeis, Louis
AU  - Buckheit, Robert W.
AU  - Clanton, David
AU  - Bu, Ming
AU  - Graham, Lisa
AU  - Schaeffer, Catherine A.
AU  - Turpin, Jim A.
AU  - Domagala, John
AU  - Gogliotti, Rocco
AU  - Bader, John P.
AU  - Halliday, Susan M.
AU  - Coren, Lori
AU  - Sowder, Raymond C.
AU  - Arthur, Larry O.
AU  - Henderson, Louis E.
TI  - Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS
AID  - 10.1126/science.270.5239.1194
DP  - 1995 Nov 17
TA  - Science
PG  - 1194--1197
VI  - 270
IP  - 5239
4099  - http://science.sciencemag.org/content/270/5239/1194.short
4100  - http://science.sciencemag.org/content/270/5239/1194.full
SO  - Science1995 Nov 17; 270
AB  - Strategies for the treatment of human immunodeficiency virus-type 1 (HIV-1) infection must contend with the obstacle of drug resistance. HIV-1 nucleocapsid protein zinc fingers are prime antiviral targets because they are mutationally intolerant and are required both for acute infection and virion assembly. Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity. The compounds were highly synergistic with other antiviral agents, and resistant mutants have not been detected. Zinc finger-reactive compounds may offer an anti-HIV strategy that restricts drug-resistance development.