PT  - JOURNAL ARTICLE
AU  - Weber, Georg F.
AU  - Ashkar, Samy
AU  - Glimcher, Melvin J.
AU  - Cantor, Harvey
TI  - Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
AID  - 10.1126/science.271.5248.509
DP  - 1996 Jan 26
TA  - Science
PG  - 509--512
VI  - 271
IP  - 5248
4099  - http://science.sciencemag.org/content/271/5248/509.short
4100  - http://science.sciencemag.org/content/271/5248/509.full
SO  - Science1996 Jan 26; 271
AB  - The CD44 family of surface receptors regulates adhesion, movement, and activation of normal and neoplastic cells. The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44. Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. This mechanism may also be exploited by tumor cells to promote metastasis formation.