RT Journal Article
SR Electronic
T1 Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
JF Science
JO Science
FD American Association for the Advancement of Science
SP 509
OP 512
DO 10.1126/science.271.5248.509
VO 271
IS 5248
A1 Weber, Georg F.
A1 Ashkar, Samy
A1 Glimcher, Melvin J.
A1 Cantor, Harvey
YR 1996
UL http://science.sciencemag.org/content/271/5248/509.abstract
AB The CD44 family of surface receptors regulates adhesion, movement, and activation of normal and neoplastic cells. The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44. Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. This mechanism may also be exploited by tumor cells to promote metastasis formation.