PT - JOURNAL ARTICLE AU - Lois, Carlos AU - GarcĂ­a-Verdugo, Jose-Manuel AU - Alvarez-Buylla, Arturo TI - Chain Migration of Neuronal Precursors AID - 10.1126/science.271.5251.978 DP - 1996 Feb 16 TA - Science PG - 978--981 VI - 271 IP - 5251 4099 - http://science.sciencemag.org/content/271/5251/978.short 4100 - http://science.sciencemag.org/content/271/5251/978.full SO - Science1996 Feb 16; 271 AB - In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.