PT  - JOURNAL ARTICLE
AU  - Lois, Carlos
AU  - García-Verdugo, Jose-Manuel
AU  - Alvarez-Buylla, Arturo
TI  - Chain Migration of Neuronal Precursors
AID  - 10.1126/science.271.5251.978
DP  - 1996 Feb 16
TA  - Science
PG  - 978--981
VI  - 271
IP  - 5251
4099  - http://science.sciencemag.org/content/271/5251/978.short
4100  - http://science.sciencemag.org/content/271/5251/978.full
SO  - Science1996 Feb 16; 271
AB  - In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.