RT Journal Article SR Electronic T1 Chain Migration of Neuronal Precursors JF Science JO Science FD American Association for the Advancement of Science SP 978 OP 981 DO 10.1126/science.271.5251.978 VO 271 IS 5251 A1 Lois, Carlos A1 GarcĂ­a-Verdugo, Jose-Manuel A1 Alvarez-Buylla, Arturo YR 1996 UL http://science.sciencemag.org/content/271/5251/978.abstract AB In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.