RT Journal Article
SR Electronic
T1 Chain Migration of Neuronal Precursors
JF Science
JO Science
FD American Association for the Advancement of Science
SP 978
OP 981
DO 10.1126/science.271.5251.978
VO 271
IS 5251
A1 Lois, Carlos
A1 García-Verdugo, Jose-Manuel
A1 Alvarez-Buylla, Arturo
YR 1996
UL http://science.sciencemag.org/content/271/5251/978.abstract
AB In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.