PT  - JOURNAL ARTICLE
AU  - Schekman, Randy
AU  - Orci, Lelio
TI  - Coat Proteins and Vesicle Budding
AID  - 10.1126/science.271.5255.1526
DP  - 1996 Mar 15
TA  - Science
PG  - 1526--1533
VI  - 271
IP  - 5255
4099  - http://science.sciencemag.org/content/271/5255/1526.short
4100  - http://science.sciencemag.org/content/271/5255/1526.full
SO  - Science1996 Mar 15; 271
AB  - The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving compartment. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.