RT Journal Article SR Electronic T1 Coat Proteins and Vesicle Budding JF Science JO Science FD American Association for the Advancement of Science SP 1526 OP 1533 DO 10.1126/science.271.5255.1526 VO 271 IS 5255 A1 Schekman, Randy A1 Orci, Lelio YR 1996 UL http://science.sciencemag.org/content/271/5255/1526.abstract AB The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving compartment. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.