RT Journal Article
SR Electronic
T1 Coat Proteins and Vesicle Budding
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1526
OP 1533
DO 10.1126/science.271.5255.1526
VO 271
IS 5255
A1 Schekman, Randy
A1 Orci, Lelio
YR 1996
UL http://science.sciencemag.org/content/271/5255/1526.abstract
AB The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving compartment. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.