PT  - JOURNAL ARTICLE
AU  - Lanske, Beate
AU  - Karaplis, Andrew C.
AU  - Lee, Kaechong
AU  - Luz, Arne
AU  - Vortkamp, Andrea
AU  - Pirro, Alison
AU  - Karperien, Marcel
AU  - Defize, Libert H. K.
AU  - Ho, Chrystal
AU  - Mulligan, Richard C.
AU  - Abou-Samra, Abdul-Badi
AU  - Jüppner, Harald
AU  - Segre, Gino V.
AU  - Kronenberg, Henry M.
TI  - PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
AID  - 10.1126/science.273.5275.663
DP  - 1996 Aug 02
TA  - Science
PG  - 663--666
VI  - 273
IP  - 5275
4099  - http://science.sciencemag.org/content/273/5275/663.short
4100  - http://science.sciencemag.org/content/273/5275/663.full
SO  - Science1996 Aug 02; 273
AB  - The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, in turn, is likely to activate more than one receptor. The functions of the PTH/PTHrP receptor were investigated by deletion of the murine gene by homologous recombination. Most PTH/PTHrP receptor (−/−) mutant mice died in mid-gestation, a phenotype not observed in PTHrP (−/−) mice, perhaps because of the effects of maternal PTHrP. Mice that survived exhibited accelerated differentiation of chondrocytes in bone, and their bones, grown in explant culture, were resistant to the effects of PTHrP and Sonic hedgehog. These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.